Crews arrived at I-295 eastbound at Durham Road in Middletown Township around 10 p.m. to find the 46-year-old driver trapped in the 2019 Ram Promaster after striking a sign, according to Pennsylvania State Police.
Crews removed the front windshield and went through the back doors to access the driver, Penndel Fire Company said.
The driver was removed through the rear doors and taken to Saint Mary's Hospital by EMS with unknown injuries. His 14-year-old passenger was also taken by EMS to the same hospital with unknown injuries, PA State Police said.
It was unclear if the 14-year-old passenger was also trapped.
Pennsylvania State Police are investigating the crash.
Click here to follow Daily Voice Bethlehem and receive free news updates.